Kratom byproduct found in gas stations and smoke shops sparks concern

The Growing Threat of 7-OH: A Potent Substance Linked to Opioid Receptors

A new health concern is emerging in the United States, as officials warn about a powerful substance that is becoming increasingly accessible. Known as 7-hydroxymitragynine or 7-OH, this compound is a concentrated form of kratom, a plant-derived substance traditionally used for pain relief and as a stimulant. However, its potency and effects on the body have raised serious concerns among health authorities.

7-OH is considered a synthetic opioid and has been found in various forms such as drinks, powders, and tablets. These products are being sold in vape shops, gas stations, and other retail outlets across the country. The increasing availability of these substances has led to a rise in medical incidents linked to 7-OH, prompting the Department of Health and Human Services (HHS) and the Food and Drug Administration (FDA) to take action against sellers.

In a recent press release, HHS announced that the FDA is recommending a scheduling action under the Controlled Substances Act to regulate these products. FDA Commissioner Marty Makary emphasized the growing presence of vape stores, stating that they are "popping up in every neighborhood in America" and often sell addictive products like 7-OH.

The Opioid Epidemic and the Risk of 7-OH

The warnings from health officials come in the wake of previous opioid crises, with experts urging caution to avoid repeating past mistakes. Dr. Makary stated, "After the last wave of the opioid epidemic, we cannot get caught flat-footed again." He highlighted that 7-OH can be more potent than morphine, emphasizing the need for regulation and public education to prevent another surge in opioid-related issues.

Currently, there are no FDA-approved drugs containing 7-OH, and it is not permitted in dietary supplements or conventional foods. Kratom itself is derived from the leaves of a tree native to Southeast Asia, including regions like Malaysia and Thailand. These leaves contain over 40 active compounds, with mitragynine, 7-OH, and speciofoline being the most prominent.

Dual Effects of Kratom and Its Concentrated Form

Kratom is known for its dual properties, acting as a stimulant at lower doses and producing opioid-like effects at higher amounts. According to Dr. Richard Clark, medical director of the California Poison Control System, kratom interacts with opioid receptors in the brain, which has led some individuals to use it as a substitute for opioid analgesics or to manage withdrawal symptoms.

However, when isolated in its concentrated form, 7-OH becomes a highly potent analgesic. This increased potency raises concerns about potential abuse and drug-related symptoms, including dependence and withdrawal. While kratom is generally considered to have fewer severe side effects, large doses or combinations with other substances can lead to hallucinations, convulsions, coma, and, in rare cases, death.

Risks and Concerns Surrounding 7-OH Products

Experts caution that the composition of kratom products can vary significantly, and labels may not always reflect the actual contents. This lack of standardization poses risks for consumers who may believe the product is safe and natural.

Dr. Lori Karan, a professor of internal and preventive medicine, noted that while kratom is not commonly associated with major toxic effects, heavy use can lead to dependence and withdrawal. Other possible side effects include nausea, dizziness, confusion, and tremors.

During a recent press conference, HHS Secretary Robert F. Kennedy Jr. highlighted the alarming trend of 7-OH's availability, particularly in areas near schools and in low-income neighborhoods. He described the marketing tactics used by vendors, including candy-flavored products and bright colors, as "sinister."

Regulatory Actions and Public Awareness

The FDA and HHS have issued a call to action against 7-OH products, emphasizing the need for stricter regulations and increased public awareness. Despite these efforts, the agencies have made it clear that pure kratom is not considered safe for use at this time.

As the situation continues to evolve, health officials urge consumers to remain informed and cautious about the risks associated with 7-OH and other kratom-related products. The goal is to prevent another wave of the opioid crisis while ensuring that individuals have access to accurate information and safer alternatives for pain management and addiction treatment.